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They found that modafinil promoted wakefulness by inhibiting the VLPO which was dependent on noradrenergic inhibition of VLPO neurons via an α2 adrenergic receptor.Curiously, in a single of such scientific tests (Tanganelli et al 1995) destruction of serotonin neurons which has a selective neurotoxin, didn't just block modafinil’s GABA inhibitin